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Khaleej Al Arabi Branch, Abu Dhabi

800 42532 (ICLDC)
F: +971 2 404 0900

PO Box 48338
Al Khaleej Al Arabi Street
Beside Zayed Military Hospital
Abu Dhabi, United Arab Emirates

Zayed Sports City Branch, Abu Dhabi

T: 800 42532 (ICLDC)
F: +971 2 404 0900

PO Box 48338
Zayed Sports City
Between entry gates 1 & 6
Abu Dhabi, United Arab Emirates

Al Ain Branch, Al Ain

T:800 42532 (ICLDC)
F: +971 3 746 4900

PO Box 222464
Beside Tawam Hospital
Al Ain, United Arab Emirates

Mobile Diabetes Clinic, Madinat Zayed

800 42532 (ICLDC)

Al Dhafra Mall (Parking Lot)
Madinat Zayed, Al Gharbia
Abu Dhabi, United Arab Emirates

Genetic research studies examine genes, mutations and molecular interactions, leading to a better understanding of human disease.

Projects include:

Functional Genomics

• Study designed in order to analyse the genetic architecture of Emirati population diagnosed with type-2 Diabetes and identify population pharmacogenomics responses to diabetes medication

• 154 index cases have been recruited, together with 53 parental samples and 500 singletons

• Analysis (including genotyping) to be completed on samples from 2,700 participants

Urinary C-peptide to Creatinine Ratio (UCPCR)

• Study undertaken in order to study the clinical validity of UCPCR for diagnosis of Maturity Onset Diabetes of the Young (MODY)

• 778 patients have been recruited with genetic analysis completed on 97 samples

• Preliminary results support the need for Emirati-specific UCPCR and MODY calculator parameters to be implemented, for correct diagnosis. Furthermore, prevalence of MODY in the Emirati population seems to differ from the suggested prevalence in the European population

Genetic Causes of Familial Hypercholesterolaemia (FH) in the Emirati population

• Aim of this study is to determine the prevalence of FH in the Emirati population and potentially identify novel genes/mutations responsible for the condition

• 426 patients have been recruited, with genetic analysis conducted on 82 patients

• Results suggest similar incidence of mutations in canonical genes to those previously reported for other populations

• Establishment of Dyslipidaemia Registry as part of the research project

Genetic Causes of Gestational Diabetes (GDM) in the Emirati Population

• Aim of the study is to identify the number of MODY patients to be found among Emirati women with GDM as the incidence and prevalence of monogenic diabetes among this group of patients is unknown. This will enable improvements in diagnostics, treatment and the counselling of these women.

• 65 candidate women with GDM or history of GDM have been recruited and genetic analysis has been performed on 32 candidates so far